MAGIC Syndrome (Mouth And Genital ulcers, Inflamed Cartilage) is now believed to be Behcet's disease with relapsing polychondritis.
Major features:
(1) oral aphthous ulcerations
(2) genital ulcerations
(3) relapsing polychondritis (auricular chondritis, other sites)
Associated findings:
(1) aortitis, which can result in an aortic aneurysm
(2) anterior uveitis, scleritis, episcleritis or other ocular inflammation
(3) arthritis
(4) erythema nodosum
Laboratory findings:
(1) elevated serum inflammatory markers
(2) selected HLA types (DRB1*0401, DRB1*0404, others)
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Purpose: To evaluate a patient for clinical features of the MAGIC syndrome (Behcet's syndrome with relapsing polychondritis).
Specialty: Immunology/Rheumatology
Objective: criteria for diagnosis
ICD-10: M35.2,
