Patients with silicosis have an increased risk for an autoimmune disorder.
Autoimmune disorders associated with silicosis:
(1) rheumatoid arthritis (Caplan syndrome)
(2) scleroderma (Erasmus syndrome)
(3) systemic lupus erythematosus (SLE)
(4) mixed connective tissue disease (MCTD, Sharp’s syndrome)
(5) ANCA-associated vasculitis (Wegener’s, pauci-immune small vessel vasculitis)
Diagnostic features:
(1) no evidence of autoimmune disease prior to silica exposure
(2) onset of autoimmune disorder after silica exposure
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Specialty: Toxicology, Emergency Medicine, Critical Care
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