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Risk Factors for Atazanavir Urolithiasis in HIV-Positive Patient

Purpose: To identify an HIV-positive patient who may be at risk for urolithiasis while being treated with atazanavir.

Description

Couzigou et al reported risk factors for urolithiasis in HIV-positive patients treated with the protease inhibitor atazanavir. These can help identify a patient at increase risk for urinary tract lithiasis and may suggest ways to reduce the risk. The authors are from multiple hospitals in France.


 

Patient selection: HIV-positive and receiving atazanavir therapy

 

Diagnosis of atazanavir lithiasis: infrared spectrophotometry

 

Risk factors for urolithiasis:

(1) low fluid intake

(2) high urine pH (more alkaline)

(3) past history of urinary lithiasis

 

Potential risk factors:

(1) coinfection with HCV

(2) severe liver dysfunction

 

Interventions to reduce risk:

(1) low fluid intake: increase fluid intake

(2) high urine pH: acidify the urine

(3) past history of urinary lithiasis: control relevant risk factors

 


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Specialty

Objective

ICD-10