Antisynthetase Syndrome | Clinical & Laboratory Features

 

Antisynthetases are autoantibodies that target synthetases which are enzymes that catalyze the acetylation of transfer RNAs (tRNA synthetases).

 

Clinical features:

(1) interstitial lung disease with or without hemoptysis

(2) polyarthritis

(3) inflammatory myositis

(4) fever

(5) Raynaud's phenomenon

(6) "mechanic's hands" (thickened and cracked skin on the fingers and palms)

(7) variable skin rash

 

Antisynthetases include:

(1) anti-Jo1 (most common)

(2) anti-PL-12 (alanyl-tRNA synthetase)

(3) anti-PL-7

(4) other