Patients with Guillain-Barre Syndrome (GBS) and related disorders may have anti-ganglioside antibodies in their serum. Neurological sites involved by the disease are often rich in the target gangliosides.
The most common antibody is anti-GQ1b.
However, other antiganglioside antibodies may also be present:
(1) anti-GM1
(2) anti-GM2
(3) anti-GD1a
(4) anti-GalNAc-GD1a
(5) anti-GD1b
(6) anti-GT1b
The presence of one or more of the antibodies supports the diagnosis of GBS spectrum disorder.
If anti-GQ1b is absent, then it is important to test for the other antibodies before reaching any conclusion.
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