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Angiotensin Receptor Blocker (ARB) Fetopathy

Purpose: To identify features of ARB fetopathy in a neonate exposed to an angiotensin receptor blocker (ARB) during pregnancy.

Description

Treatment of a pregnant woman with an angiotensin receptor blocking (ARB) agent can result in a number of changes in the fetus termed the ARB fetopathy. The findings are similar those seen with angiotensin converting enzyme (ACE) inhibitors. Therapy with an ARB is contraindicated during pregnancy.


 

Fetal changes may include:

(1) oligohydramnios

(2) renal insufficiency

(3) pulmonary hypoplasia (secondary to the renal insufficiency)

(4) limb contractures

(5) limb deformities including polydactyly

 

The fetus may be born prematurely.

 

The neonate may develop:

(1) hypotension

(2) end-stage renal failure

(3) salt-losing nephrogenic diabetes insipidus

 


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Specialty

Objective

ICD-10