Tokunaga et al evaluated patieints with angioimmunoblastic T-cell lymphoma. They developed a prognostic index. The authors are from multiple hospitals and universities in Japan.
Patient selection: angioimmunoblastic T-cell lymphoma (AITL) in Japan
Parameters:
(1) age in years
(2) WBC count
(3) hemoglobin and gender
(4) platelet count per µL
(5) serum IgA concentration
(6) extranodal involvement
|
Parameter |
Finding |
Points |
|
age in years |
<= 60 years of age |
0 |
|
|
> 60 years of age |
1 |
|
WBC count |
<= 10,000 per µL |
0 |
|
|
> 10,000 per µL |
1 |
|
hemoglobin and gender |
male and Hgb >= 13 g/dL |
0 |
|
|
male and Hgb < 13 g/dL |
1 |
|
|
female and Hgb >= 11 g/dL |
0 |
|
|
female and Hgb < 11 g/dL |
1 |
|
platelet count |
>= 150,000 per µL |
0 |
|
|
< 150,000 per µL |
1 |
|
serum IgA |
<= 400 mg/dL |
0 |
|
|
> 400 mg/dL |
1 |
|
extranodal involvement |
0 or 1 |
0 |
|
|
> 1 |
1 |
total score =
= SUM(points for all 6 parameters)
Interpretation:
• minimum score: 0
• maximum score: 6
• The higher the score the worse the prognosis.
|
Total Score |
Risk |
50% Overall Survival |
|
0 or 1 |
low |
0.8 years |
|
2 |
low-intermediated |
1.8 years |
|
3 |
high-intermediate |
4.3 years |
|
4, 5 or 6 |
high |
8.2 years |
Specialty: Hematology Oncology
