The amount of drug in the body and the plasma concentration after the Nth dose of an oral drug can be calculated from the kinetic data.
maximum amount of drug in the body after the Nth dose =
= (fraction of drug absorbed) * (maintenance dose) * (1 - EXP((-1) * N * (elimination rate constant) * (dosing interval))) / (1 - EXP((-1) * (elimination rate constant) * (dosing interval)))
minimum amount of drug in the body after the Nth dose =
= (maximum amount of drug after the Nth dose) * EXP((-1) * (elimination rate constant) * (dosing interval))
plasma concentration in mg/L =
= (amount of drug in the body in mg) / (volume of distribution in liters)
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Specialty: Toxicology, Emergency Medicine, Critical Care
ICD-10: ,
