Amiodarone-Associated Optic Neuropathy

 

Clinical features:

(1) slow and insidious onset

(2) bilateral vision loss with visual field defects

(3) usually associated with bilateral edema of optic disc

(4) gradual improvement in vision after discontinuation of the amiodarone but some residual impairment may persist

 

Amiodarone may also be associated with corneal microdeposits and anterior subcapsular lens opacities.

 

Differential diagnosis:

(1) other drug-induced visual impairments

(2) anterior ischemic optic neuropathy (usually sudden onset and unilateral vision loss)