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Albumin-Indocyanine Green Evaluation (ALICE) Grade of Kokudo et al for a Patient Undergoing Hepatic Resection

Description

Kokudo et al developed the Albumin-Indocyanine Green Evaluation (ALICE) Grade for evaluating a patient prior to hepatic resection. The authors are from the University of Tokyo, Saitama Cancer Center, University Hospital Centre Hospitalier Universitaire Vaudois, Japanese Red Cross Medical Center, and University College London.


 

Patient selection: hepatocellular carcinoma prior to hepatic resection

 

Parameters:

(1) serum albumin in g/L

(2) indocyanine green retention rate at 15 minutes in percent (ICG R15)

 

linear predictor =

= (0.663 * LOG10(ICG R15)) - (0.0718 * (serum albumin))

Linear Predictor

ALICE

< -2.20

Grade 1

-2.20 to -1.88

Grade 2a

-1.89 to -1.39

Grade 2b

> -1.39

Grade 3

 

The ALICE grade correlated with blood transfusion requirements and complications.

 

ALICE

30-Day Mortality After Surgery

10 Year Overall Survival (Derivation and Validation Groups)

Grade 1

0%

3-10%

Grade 2

1.3%

27%

Grade 3

5.3%

54*

 

Performance:

• A ROC curve analysis was performed but the value not reported. A rough estimate of Figure 5 suggests a value around 0.70.

 


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