| To adjust the daily dose of warfarin for a patient being initiated on long-term amiodarone therapy.|
|Hematology, Hematology, Clinical Pharmacology, Pharmaceutical Medicine|
|drug interactions, dosage adjustments|
|I80, I81, I82|
Initiation of amiodarone therapy in a patient being treated with oral warfarin can result in a drug interaction with the potential for over-anticoagulation. This effect is proportional to the dose of amiodarone, and a patient should have the daily warfarin dose adjusted accordingly. The authors are from the University of Illinois at Chicago and the University of Science in Philadelphia.