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Adjustment in the Daily Warfarin Dose for a Patient Receiving Long-Term Amiodarone Therapy

Purpose:

To adjust the daily dose of warfarin for a patient being initiated on long-term amiodarone therapy.

Specialty:

Hematology, Hematology, Clinical Pharmacology, Pharmaceutical Medicine

Objective:

drug interactions, dosage adjustments

ICD-10:

I80, I81, I82

Description:

Initiation of amiodarone therapy in a patient being treated with oral warfarin can result in a drug interaction with the potential for over-anticoagulation. This effect is proportional to the dose of amiodarone, and a patient should have the daily warfarin dose adjusted accordingly. The authors are from the University of Illinois at Chicago and the University of Science in Philadelphia.

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