Liver Injury Unit (LIU) Scoring System for Pediatric Acute Liver Failure (PALF)

 

Patient selection: pediatric patient with acute liver failure

 

Outcome: Poor outcome was death or liver transplant.

 

Parameters:

(1) admission total bilirubin in mg/dL

(2) admission prothrombin time in seconds

(3) admission INR

 

admission score 1 =

= (6.9 * (admission total bilirubin)) + (4 * (admission PT))

 

admission score 2 =

= (8.4 * (admission total bilirubin)) + (50 * (admission INR))

 

Interpretation:

• The higher the score the worse the prognosis.

• Evaluation of survival was based on quartiles.

 

NOTE: The captions to the figures in the original paper suggest that the figures were switched. The cutoffs with the figure do not match the text on page 4. In Lu et al 2013 the data in Figure 1A (score 2) is the same as Figure 3 in Lu et al 2008 Figure 3 (admission score using INR). The cutoffs for Figure 1B for Lu et al 2013 (admission score using INR) match Figure 2 (score 1) for Lu et al 2008.

 

Caption for Figure 1 goes with figure for Figure 3 for Lu et al 2008.

Caption for Figure 2 goes with figure for Figure 1.

Caption for Figure 3 goes with figure for Figure 2.

Caption for Figure 4 goes with figure for Figure 4.

 

Based on best guess:

Score 1 (with PT)	Alive and Transplant Free at 16 Weeks
0 to 115	79%
116 to 172	69%
173 to 232	69%
>= 233	43%

 

 

Score 2 (with INR)	Alive and Transplant Free at 16 Weeks
0 to 160	86%
161 to 211	77%
212 to 309	69%
>= 310	31%